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T h1 and T h2 polymorphisms in S jögren's syndrome and rheumatoid arthritis
Author(s) -
Souza Thayse Rodrigues,
Albuquerque Tavares Carvalho Alessandra,
Duarte Ângela Pinto,
Porter Stephen R.,
Leão Jair C.,
Gueiros Luiz Alcino
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12149
Subject(s) - rheumatoid arthritis , sialadenitis , medicine , genotype , saliva , rheumatoid factor , interleukin , tumor necrosis factor alpha , gene polymorphism , salivary gland , immunology , pathology , gene , cytokine , biology , genetics
Background Sjogren's syndrome is characterized by T ‐cell infiltration of exocrine glands leading to parenchymal destruction and impaired glandular function. This process is orchestrated by cytokines, whose secretion can be regulated by genetic polymorphisms. Materials and Methods The aim of this study was to investigate the influence of interleukin‐6 ‐174 G / C , interleukin‐10 ‐1082 G / A , tumor necrosis factor‐α ‐308 G / A , interferon‐γ +874 A / T gene polymorphisms in ( RA ) and secondary S jögren's syndrome ( sSS ). A study sample that comprised of 138 B razilian patients was divided into three groups: RA ( n = 66), sSS ( n = 20), and healthy controls – C ( n = 52). Patients were subjected to S chirmer's test, unstimulated salivary flow rate, biopsy of minor salivary glands, and serological tests for diagnosing SS . Genomic DNA was obtained from saliva samples and submitted to genotyping. The association between genotypes/alelle frequency and SS susceptibility was tested, as well as their association with clinical features of SS . Results Tumor necrosis factorα ( TN Fα)‐308 GA polymorphisms differed significantly between AR , SS , and C patients ( P = 0.008). IL ‐6 overall G carriers and TNF α A carriers had a higher risk of presenting SS ( P = 0.021). IL ‐6 polymorphism distribution was also distinctive regarding lymphocytic infiltration at the minor salivary glands ( P = 0.026) and S chirmer's test ( P = 0.035). Conclusion These results suggest that IL ‐6 ‐174 GC and TNF α‐308 GA gene polymorphisms are associated with susceptibility to SS . Additionally, IL ‐6 polymorphism could influence lymphocytic infiltration of salivary glands and diminish lachrymal gland function.