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Prevalence of high‐risk human papillomavirus type 16 and 18 in oral and cervical cancers in population from G ujarat, W est I ndia
Author(s) -
Patel Kinjal R.,
Vajaria Bhairavi N.,
Begum Rasheedunnisa,
Desai Ava,
Patel Jayendra B.,
Shah Franky D.,
Shukla Shilin N.,
Patel Prabhudas S.
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12147
Subject(s) - medicine , cervical cancer , cancer , population , human papillomavirus , hpv infection , carcinogenesis , oncology , vaccination , gynecology , gastroenterology , immunology , environmental health
Background Oral and cervical cancers are major malignancies in men and women, respectively, in India. This study evaluated occurrence of human papillomavirus ( HPV ) 16 and 18 infections in oral and cervical cancers to estimate HPV ‐associated burden of these cancers in the population from G ujarat, W est I ndia. Methods A total of 97 malignant oral carcinoma tissues and 52 cervical carcinoma tissues were analyzed by type‐specific PCR for the presence of HPV type 16 and 18 infections. Results None of the oral cancer patients revealed the presence of HPV type 16 and 18 infection. In cervical cancer, 31 (59.6%) patients were infected with HPV 16 and 18. Of these 31 HPV ‐positive cervical cancer patients, 28 (90.3%) were infected with HPV 16 and 3 (9.7%) were infected with HPV 18. Conclusion The results suggested that HPV 16 and 18 do not play an important role in oral carcinogenesis in the population from Gujarat, West India. However, HPV 16 is highly prevalent in the cervical cancer patients, which may be considered for planning of prevention programs such as screening and vaccination in women from this region.