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Delayed progression of condylar cartilage degeneration, by reduction of the discoidin domain receptor 2, in the temporomandibular joints of osteoarthritic mouse models
Author(s) -
Salazar Armando,
Polur Ilona,
Servais Jacqueline M.,
Li Yefu,
Xu Lin
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12137
Subject(s) - discoidin domain , temporomandibular joint , cartilage , condyle , medicine , osteoarthritis , type ii collagen , pathology , degeneration (medical) , anatomy , receptor , alternative medicine , receptor tyrosine kinase
Objective To determine whether reduction of the discoidin domain receptor 2 (Ddr2) delays the progression of condylar cartilage degeneration in the temporomandibular joint ( TMJ ) of mouse models with osteoarthritis ( OA ). Methods Double‐heterozygous ( Col11a1 ‐ and Ddr2 ‐haploinsufficiency, Col11a1 +/− ; Ddr2 +/− ) mice were generated. TMJ s of Ddr2 +/− mice were subjected to partial discectomy. Condylar cartilage from the TMJ of Col11a1 +/− ; Ddr2 +/− mice, surgically treated (discectomy) Ddr2 +/− mice, and their corresponding controls was characterized by means of histology and evaluated using a scoring system specific to mouse joints. Results The progression of condylar cartilage degeneration was significantly delayed in the TMJ of Col11a1 +/− ; Ddr2 +/− mice compared with those of the Col11a1 +/− mice. The progression of condylar cartilage degeneration in the TMJ of Ddr2 +/− mice following discectomy was also significantly delayed when compared with their wild‐type littermates. Conclusion Reduced expression of Ddr2 delays the progression of condylar cartilage degeneration, induced either by type XI collagen haploinsufficiency or by a partial discectomy, in TMJ .