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Clinical efficacy of new aloe vera‐ and myrrh‐based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double‐blind, vehicle‐controlled study
Author(s) -
Mansour Ghada,
Ouda Soliman,
Shaker Ahmed,
Abdallah Hossam M.
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12130
Subject(s) - aloe vera , medicine , erythema , recurrent aphthous stomatitis , mouth rinse , stomatitis , placebo , randomized controlled trial , double blind , dermatology , clinical trial , dentistry , traditional medicine , surgery , alternative medicine , pathology
Objective To evaluate the clinical efficacy, and safety of newly customized natural oral mucoadhesive gels, containing either aloe vera or myrrh as active ingredients, in the management of minor recurrent aphthous stomatitis ( M i RAS ). Subjects and Methods Ninety subjects with M i RAS were recruited from O ral M edicine C linic, at F aculty of D entistry, K ing Abdulaziz U niversity, S audi A rabia, for this randomized, double‐blind, placebo‐controlled study. Two new natural gels, containing aloe vera and myrrh, were prepared in a concentration of (0.5% w/w), in addition to a plain mucoadhesive gel used as a placebo. Patients with fresh ulcers (<48‐h duration) were instructed to apply either one of the three gels four times a day for a period of 5 days. Clinical efficacy was investigated in the form of changes in ulcer size, pain intensity, erythema, and exudation at days 4 and 6 of study entry. Participants were interviewed for the emergence of any side effects. Results 76.6% of patients using aloe gel showed complete ulcer healing, 86.7%, and 80% of them revealed subsidence of erythema and exudation, respectively, especially at day 6 visit, whereas 76.7% of myrrh‐treated patients revealed almost absence of pain at day 6. No side effects were encountered with the use of any of the three gels. Conclusion The new formulated aloe‐ and myrrh‐based gels proved to be effective in topical management of M i RAS . Aloe was superior in decreasing ulcer size, erythema, and exudation; whereas myrrh resulted in more pain reduction.