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Prognostic role of salivary CD 44sol levels in the follow‐up of laryngeal carcinomas
Author(s) -
Allegra Eugenia,
Trapasso Serena,
Boria Alessandro,
Aragona Teodoro,
Pisani Davide,
Belfiore Antonino,
Garozzo Aldo
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12129
Subject(s) - medicine , otorhinolaryngology , saliva , head and neck cancer , surgery , prospective cohort study , head and neck surgery , cancer , gastroenterology
Background The purpose of this study was to verify CD 44sol levels in the saliva of patients during follow‐up after surgery for laryngeal cancer, to compare them with those registered at the time of diagnosis (pre‐intervention) in the same patients, and to assess the reliability of the test as a prognostic indicator. Methods This prospective study was performed on 21 patients having laryngeal cancer who underwent surgery at the D ivision of O tolaryngology, U niversity of C atanzaro; twelve adults with head and neck benign disease were recruited to form a control group. For each patient, the clinical–anamnestic data were collected and entered into a database. The sampling of undiluted saliva was performed the day before surgery and during the follow‐up, every 3 months. Salivary CD 44sol levels were determined using the ELISA method. Results Mean salivary CD 44sol levels in the patients group before surgery (pre‐intervention) were significantly higher than those in the control group (70.75 ± 33.8 vs. 12.4 ± 8.7 ng/ml). At follow‐up performed 3 months after surgery, 18 of 21 (85.71%) patients had a reduction in salivary CD 44sol levels, with a mean value of 50.1 ng/ml; the difference between these and pre‐intervention CD 44sol levels was statistically significant ( P < 0.04). Mean CD 44sol levels of 31.1 ng/ml at 6 months post‐intervention have been determined in 19 of 21 enrolled patients; none of the 19 patients have actual signs of recurrence. Conclusions These data seem to show that the determination of salivary CD 44sol levels can represent a promising prognostic test in laryngeal carcinomas.