Premium
Cellular cannibalism in central and peripheral giant cell granuloma of the oral cavity can predict biological behavior of the lesion
Author(s) -
Sarode Sachin C.,
Sarode Gargi S.
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12119
Subject(s) - central giant cell granuloma , cd68 , lesion , cannibalism , giant cell , pathology , immunohistochemistry , medicine , peripheral blood mononuclear cell , cell , epulis , biology , in vitro , genetics , biochemistry , botany , larva
Background Cancer cannibalism is used to differentiate benign tumors from malignant, but recently the phenomenon has been demonstrated in giant cell tumor of tendon sheath (localized type). Microscopically and pathogenetically, this tumor is similar to central giant cell granuloma ( CGCG ) and peripheral giant cell granuloma ( PGCG ) of oral cavity. Hence, attempt has been made to study the cannibalistic giant cells ( GC s) in CGCG and PGCG with their correlation with the biological behavior. Methods Surgically treated 16 CGCG and 23 PGCG cases with adequate clinical and radiographic documentation were selected. Quantification of cannibalistic GC s was performed using routine HE stain. Hundred GC s were examined in each section, and number of cannibalistic cells was expressed in percentage. Ten cases were randomly selected for further immunohistochemical analysis with CD 68 and bcl‐2. Results Cannibalism was found in all the cases (100%). The frequency of occurrence of cannibalistic GC s ranged from 20% to 56% with a mean of 33.62 ± 8.9. CGCG showed significantly higher mean cannibalistic GC frequency (38.06 ± 10.15) than PGCG (30.04 ± 5.63). In aggressive CGCG , mean cannibalistic GC frequency was significantly higher (42.20 ± 10.4) than non‐aggressive type (31.17 ± 6.014). Similarly, recurrent cases showed significantly higher mean cannibalistic cell frequency (43 ± 6.26) than non‐recurrent cases (30.81 ± 6.66). Immunohistochemistry results showed histiocytic nature of GC s as well as mononuclear cells. The internalized cells did not expressed bcl‐2, suggesting that the internalization induces apoptotic cell death. Conclusion Assessment of frequency of cannibalistic cells in CGCG and PCGC could help in predicting the biological behavior of the tumor.