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High CDC 20 expression is associated with poor prognosis in oral squamous cell carcinoma
Author(s) -
Moura Inês M. B.,
Delgado Maria L.,
Silva Patrícia M. A.,
Lopes Carlos A.,
do Amaral José B.,
Monteiro Luís S.,
Bousbaa Hassan
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12115
Subject(s) - cdc20 , securin , cell cycle , immunohistochemistry , cyclin b1 , cancer research , anaphase promoting complex , biology , cell cycle checkpoint , medicine , cancer , pathology , anaphase , cyclin dependent kinase 1
Objectives Human C ell D ivision C ycle 20 ( CDC 20) homolog is a crucial target of the spindle assembly checkpoint. It is an activator of the Anaphase‐ P romoting C omplex/ C yclosome ( APC /C) which promotes anaphase onset and mitotic exit through the ubiquitination of securin and cyclin B 1. Overexpression of CDC 20 was previously reported in oral squamous cell carcinoma ( OSCC ). Here, we propose to explore the clinicopathological significance of CDC 20 overexpression and its potential use as a prognostic marker in OSCC . Methods Using tissue microarray technology, we analyzed CDC 20 expression in 65 primary OSCC tissues by immunohistochemistry. Statistical analysis was performed to evaluate the clinicopathological and prognostic significance of CDC 20 expression in OSCC . Results Of the 65 cases of patients with OSCC studied, 37 (56.9%) showed high CDC 20 protein expression. No clinicopathological features were correlated with CDC 20 expression. Importantly, in univariable analysis, OSCC patients with higher CDC 20 protein expression showed significantly shorter cancer‐specific survival rate ( P = 0.018). Multivariable analysis identified high CDC 20 expression as an independent prognostic factor ( P = 0.032). Conclusion High CDC 20 expression is associated with poor prognosis in OSCC and may be used to identify high‐risk OSCC patients and may serve as a therapeutic target.