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DNA repair gene polymorphisms and risk of head and neck cancer in the T unisian population
Author(s) -
Khlifi Rim,
Kallel Imen,
Hammami Bouthaina,
HamzaChaffai Amel,
Rebai Ahmed
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12114
Subject(s) - genotype , single nucleotide polymorphism , dna repair , head and neck cancer , medicine , population , population stratification , case control study , nucleotide excision repair , oncology , genetics , biology , cancer , gene , environmental health
Altered activity of DNA repair enzymes may be involved in modulating cancer susceptibility and pathogenesis of head and neck cancer ( HNC ). We conducted a case–control study to test the association between three common single‐nucleotide polymorphisms of XRCC 1, ERCC 2, and ERCC 3 genes with HNC risk in Tunisian patients. To the best of our knowle dge, this is the first report on polymorphisms in XRCC 1, ERCC 2, and ERCC 3 and susceptibility to HNC in our population. The genotype analyses of XRCC 1 A rg399 G ln, ERCC 2 L ys751 G ln, and ERCC 3 7122 A > G polymorphisms for 169 HNC patients, and 261 controls were performed using the PCR ‐based restriction fragment length polymorphism. Stratification of the populations according to smoking and drinking habits and occupational exposure highlighted the importance of tobacco, alcohol, and toxic substance as three risk co‐factors for the development of HNC . Our study suggests that only the XRCC 1 A rg399 G ln polymorphism was associated with the risk of HNC in the Tunisian population ( OR = 2.04; P = 0.001). Furthermore, the risk of HNC was associated with XRCC 1 A rg399 G ln polymorphism stratified by occupational exposure status ( OR = 2.29; P = 0.024). However, no statistically significant association was observed between the risk of developing HNC and the ERCC 2 Lys751Gln and ERCC 3 A > G polymorphisms. These data suggest that the XRCC 1 A rg399 G ln polymorphism is associated with an increased risk of developing HNC , because it correlates with occupational exposure in T unisian population.