Premium
The role of NEFL in cell growth and invasion in head and neck squamous cell carcinoma cell lines
Author(s) -
Huang Zhiquan,
Zhuo Ying,
Shen Zhuojian,
Wang Youyuan,
Wang Lili,
Li Haigang,
Chen Ju,
Chen Weiliang
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12109
Subject(s) - biology , cell , apoptosis , cancer research , cancer cell , cancer , head and neck squamous cell carcinoma , gene , cell culture , head and neck cancer , genetics
The neurofilament light polypeptide ( NEFL ) gene located on chromosome 8q21 is associated with the cancer of several organs and is regarded as a potential tumor suppressor gene. However, the role of the NEFL protein has not yet been studied in cancer cells. Although evidence suggests that there is a correlation between NEFL expression and cancer, studies regarding the role of the NEFL protein have been mostly limited to neurological diseases, such as Charcot–Marie–Tooth's disease ( CMT ). Most of these studies have not explored the role of NEFL in cancer cell apoptosis and/or invasion. In this study, NEFL expression was manipulated, and apoptosis and invasion were compared in head and neck squamous cell carcinoma cell lines. The results show that the expression of NEFL induces cancer cell apoptosis and inhibits invasion in these cell lines, suggesting that NEFL may play a role in cancer cell apoptosis and invasion.