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Fas L expression in articular discs of human temporomandibular joint and association with osteoarthrosis
Author(s) -
Alcântara Camejo Flavio,
Almeida Luis Eduardo,
Doetzer Andrea Duarte,
Caporal Karina São Thiago,
Ambros Viviane,
Azevedo Marina,
Alanis Luciana Reis Azevedo,
Olandoski Marcia,
Noronha Lucia,
Trevilatto Paula Cristina
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12089
Subject(s) - immunostaining , temporomandibular joint , apoptosis , medicine , immunohistochemistry , fas ligand , reduction (mathematics) , pathology , programmed cell death , chemistry , biochemistry , geometry , mathematics
Background Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis. Fas ligand (Fas L ) is an apoptosis‐inducing factor, known to trigger apoptosis through distinct signal pathways. This study aims to examine, by immunohistochemistry, the expression of Fas L in temporomandibular joint ( TMJ ) articular discs of patients with anterior disc displacement with reduction ( ADD wR) and without reduction ( ADD woR) in patients with and without osteoarthrosis ( OA ). Methods Forty‐two ( n = 42) TMJ articular discs were divided into two cut‐offs: (i) 8 control, 17 ADD wR, 17 ADD woR, and (ii) without OA ( n = 25) and with OA ( n = 17). The area of immunostaining was compared statistically between groups ( P < 0.05). Results Statistically significant differences were found in the expression of Fas L in TMJ discs between the three groups ( P = 0.001). ADD w R presented significant higher Fas L expression when compared with ADD wo R ( P < 0.001). Significant higher Fas L expression was observed in the group without OA ( P = 0.001). All patients without OA presented ADD w R , while all the patients with OA presented ADD wo R . Conclusion A higher area of in situ immunostaining of Fas L was found in temporomandibular discs with reduction, which is the less severe condition. Moreover, a reduced expression of Fas L in the discs of patients with osteoarthrosis was found, suggesting that some aspects of apoptosis might underlie the progression of TMJ disorders.