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Is there any benefit in surgery for potentially malignant disorders of the oral cavity?
Author(s) -
Balasundaram I.,
Payne K. F. B.,
AlHadad I.,
Alibhai M.,
Thomas S.,
Bhandari R.
Publication year - 2014
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12088
Subject(s) - medicine , epithelial dysplasia , malignancy , dysplasia , malignant transformation , grading (engineering) , observational study , surgery , oral cavity , pathology , dentistry , civil engineering , engineering
Oral epithelial dysplasia grading is currently recognised as the most useful prognostic indicator for predicting conversion of potentially malignant disorders of the oral cavity to squamous cell carcinoma. It is also used as a basis for deciding management options. However, the diagnosis of oral epithelial dysplasia is subjective and thus unreliable. Surgery is currently recommended for removal of high‐risk lesions; however, the evidence for its success is lacking, and in some cases, there have been reports of increased recurrence of malignancy following surgical excision. Molecular and genetic markers have been identified and show promising results in identifying which potential malignant disorders are at risk of malignant transformation. The current evidence available for prognosis of potential malignant disorders and its treatment is based on observational and retrospective data. No randomised control trials have been conducted to date to assess the efficacy of surgery in oral epithelial dysplasia. Until good quality evidence is available from well‐designed randomised control trials, experts still recommend the surgical removal of potential malignant disorders which are regarded as high risk.