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Novel therapies for oral lichen planus
Author(s) -
Thongprasom Kobkan,
Prapinjumrune Chanwit,
Carrozzo Marco
Publication year - 2013
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12083
Subject(s) - oral lichen planus , medicine , mucocutaneous zone , pimecrolimus , dermatology , thalidomide , modalities , treatment modality , intensive care medicine , tacrolimus , surgery , disease , transplantation , social science , sociology , multiple myeloma
Oral lichen planus ( OLP ) is a chronic mucocutaneous disorder commonly found in middle‐aged women. Despite the progress in research and advance in knowledge on OLP , a successful management is still difficult to achieve. The main aim of OLP treatment is to control the symptoms of the affected patients. Steroids and other immunosuppressive drugs have been recommended and widely used in the treatment of OLP . Topical corticosteroids are the mainstay of OLP treatment, but strong evidence on their effectiveness is lacking. The effectiveness of alternative ways of managing OLP has been recently reported. Topical aloe vera, topical pimecrolimus and oral curcuminoids are the most promising of the new treatment modalities. Other interesting modalities are topically applied thalidomide and amlexanox. Nevertheless, the careful assessment between the risks and benefits of these drugs is crucial and larger and well‐conducted trials need to confirm the above encouraging results.