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Immunohistochemical expression of oestrogen receptor‐α and progesterone receptor in salivary gland tumours
Author(s) -
Kolude Bamidele,
Adisa Akinyele,
Adeyemi Bukola,
Lawal Ahmed
Publication year - 2013
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12071
Subject(s) - immunohistochemistry , salivary gland , pathology , progesterone receptor , mammary gland , histology , medicine , oestrogen receptor , statistical significance , estrogen receptor , receptor , breast cancer , cancer
Background The mammary and salivary glands are tubulo‐acinar exocrine glands, sharing similar morphological characteristics and tumour histology. It is logical to postulate that they may have similar tumour biology. This study was carried out to define the expression of oestrogen‐α ( ER ‐α) and progesterone ( PR ) in salivary gland tumours ( SGT s) presenting at the University College Hospital, Ibadan. Methods Formalin‐fixed, paraffin‐embedded tissue samples of different salivary gland neoplasms were processed for antibodies to ER ‐α and PR using the specifications of the manufacturer. Two independent investigators reviewed the slides scoring the pattern and intensity of staining as follows: negative (0), weakly positive (+1), moderately positive (+2) and strongly positive (+3). Data were analysed using version 16 of the Statistical Package for Social Sciences ( SPSS 16). The level of significance was set at P < 0.05. Results A total of 40 SGT s from 19 males (47.5%) and 21 females (52.5%) were utilised. There were 15 benign and 25 malignant SGT s. ER expression in benign SGT s was 6.7%, while in malignant SGT s, it was 28.0%. There was no statistically significant difference in the gender and mean age distribution between patients with or without positive ER ‐α expression (χ 2 = 0.37, P = 0.59 Fisher's exact test; t = 0.054, P = 0.96, respectively). About 66.7% of high‐grade SGT s was positive for ER while only 20% of the low‐grade lesions were positive. Conclusion This study showed that ER ‐α was expressed more in the high‐grade malignant SGT s compared with the low‐grade malignant SGT s and the benign SGT s.