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Effects of lawsone methyl ether mouthwash on oral C andida in HIV ‐infected subjects and subjects with denture stomatitis
Author(s) -
Nittayananta Wipawee,
Pangsomboon Kanokporn,
Panichayupakaranant Pharkphoom,
Chanowanilnara,
Chelae Sureerat,
Vuddhakul Varaporn,
Sukhumungoon Pharanai,
Pruphetkaew Nannapat
Publication year - 2013
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12060
Subject(s) - medicine , stomatitis
Objectives To determine (i) effects of lawsone methyl ether ( LME ) mouthwash on antifungal drug resistance of oral C andida , (ii) effects of LME mouthwash on changes in genotype of oral C andida , and (iii) allergy and subjects' satisfaction on LME mouthwash in comparison with chlorhexidine ( CHX ). Materials and methods A randomized clinical trial was conducted in HIV ‐infected subjects and denture wearers receiving either LME or CHX mouthwash. Candidal culture by oral rinse technique was performed as baseline and after using the mouthwash for 2 weeks. Antifungal drug resistance and changes in genotype of oral C andida were assessed by microdilution assay, inverted repeat polymerase chain reaction and restriction fragment length polymorphism assays, respectively. Allergy and subjects' satisfaction on the mouthwashes were recorded. Statistical analysis was performed using C hi‐squared and F isher's exact tests. Results Twenty‐nine HIV ‐infected subjects (age range, 26–54 years; mean age, 41 years) and 38 denture wearers (age range, 27–76 years; mean age, 55 years) were enrolled. C . albicans was the most common specie found in both groups followed by C . tropicalis , C . parapsilosis, and C . glabrata . Neither antifungal drug resistance nor significant changes in genotyping of C andida were noted among those receiving LME mouthwash. Subjects' satisfaction on taste and smell of LME mouthwash was comparable to that of CHX . Conclusions Use of LME mouthwash for 2 weeks neither led to antifungal drug resistance nor significant changes in genotype of oral C andida . Thus, LME may be an alternative mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease.