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The role of angiogenin in pT1‐T2 tongue carcinoma neo‐angiogenesis and cell proliferation: an exploratory study
Author(s) -
Marioni Gino,
Staffieri Alberto,
Fasanaro Elena,
Stramare Roberto,
Giacomelli Luciano,
Bernardi Elena,
Val Matteo,
Stellini Edoardo,
Filippis Cosimo,
Blandamura Stella
Publication year - 2013
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12053
Subject(s) - angiogenin , tongue , angiogenesis , medicine , carcinoma , immunohistochemistry , endoglin , pathology , cancer , cell growth , cancer research , biology , stem cell , cd34 , genetics
Background Angiogenin ( ANG ) is a member of the ribonuclease superfamily and of medical interest largely because it supports the growth of primary and metastatic malignancies. This study is the first to investigate the potential role of ANG in tongue carcinoma neo‐angiogenesis and cancer cell proliferation. Methods Angiogenin expression (in carcinoma cells and endothelial intratumor vessel cells), CD105‐assessed micro‐vessel density (MVD), and MIB‐1 expression were correlated with prognostic parameters in 28 primarily consecutively operated pT 1‐T2 tongue carcinomas (squamous cell carcinoma [SCC]). Whenever feasible, a computer‐based image analysis system was used for the immunohistochemical reaction analysis. Results No significant correlations emerged between ANG expression in the tongue carcinoma cells or endothelial intratumor vessel cells and tongue SCC recurrence rate or disease‐free survival ( DFS ). ANG expression was also unrelated to CD 105‐assessed MVD or MIB ‐1 expression. Conversely, CD 105‐assessed MVD correlated directly with recurrence rate ( P = 0.02) and DFS was significantly shorter in cases with CD 105‐assessed MVD >167 micro‐vessels/mm 2 than in those with CD 105‐assessed MVD ≤167 micro‐vessels/mm 2 ( P = 0.042). Conclusions Our results support the hypothesis that CD 105‐assessed MVD would be a valuable parameter for predicting which patients with tongue SCC are at greatest risk of disease recurrence. Despite our study results, the role of ANG in tongue carcinoma warrants further investigation in larger series.