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Inflammatory factors gene polymorphism in recurrent oral ulceration
Author(s) -
Sun Mao,
Fu ShanMin,
Dong GuangYing,
Wu Dan,
Wang GuoXia,
Wu Yuanming
Publication year - 2013
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/jop.12048
Subject(s) - genotype , allele , gene polymorphism , biology , polymorphism (computer science) , immunology , medicine , gene , gastroenterology , genetics
Background Some inflammatory factors play an important role in recurrent oral ulceration ( ROU ). The genetics mechanism of expression level of inflammatory factors is not clear in ROU , but from genetics the expression level of inflammatory factors at least partly depend on the gene polymorphisms. Therfore, we decided to investigate inflammatory factors gene polymorphism and its association with the susceptibility of recurrent oral ulceration in Chinese. Methods Genomic DNA was obtained from 42 subjects with recurrent oral ulceration, 86 subjects of healthy control individuals.Genotypes and alleles of 10 genes and 17 polymorphisms sites were analyzed by Mass‐ ARRAY Analyzer method. Then, the differences in distribution of each genotype and allele were compared. Results The statistical differences in distribution of TNF ‐α (rs1800629 and rs1800630) genotype and allele were observed among the groups with recurrent oral ulceration and healthy control individuals ( P < 0.01), while VEGFA (rs1570360, rs833061, and rs2010963), EGF (rs4444903), TNF (rs361525), IL 10 (rs1800896, rs1800872), IL 2 (rs2069762), IL 4 (rs2243250), Fas (rs1800682, rs2234767), IL 12A (rs2243115, rs568408), IL 12B (rs3212227), and IFNG (rs2430561) showed no statistical differences of genotype and allele in controls as compared to those in patients. Conclusions This study suggests that the TNF ‐α (rs1800629 and rs1800630) genotype is an indicator for the susceptibility of recurrent oral ulceration.