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Efficacy and adverse events of 4% articaine compared with 2% lidocaine on primary molar extraction: A randomised controlled trial
Author(s) -
Massignan Carla,
Silveira Santos Pablo,
Cardoso Mariane,
Bolan Michele
Publication year - 2020
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/joor.12989
Subject(s) - articaine , molar , lidocaine , medicine , adverse effect , dentistry , extraction (chemistry) , randomized controlled trial , anesthesia , chemistry , chromatography
Abstract Background There is no consensus regarding the most effective anaesthetic solution for children; nerve block, especially mandibular, can be difficult for general dentists. Therefore, the study aims to compare the efficacy and the adverse events of articaine 4% with epinephrine 1:100 000 with lidocaine 2% with epinephrine 1:100 000 for primary molar extraction using buccal infiltration. Methods These are data from a parallel triple‐blind randomised controlled trial with a computer‐generated allocation treatment. Forty‐three children aged 6‐10 years with a clinical and radiographic indication of primary molar extraction were enrolled. The intervention was local buccal infiltration with articaine 4% compared with lidocaine 2%. The main outcome was pain during anaesthetic injection and tooth extraction. Adverse events were examined as secondary outcomes. Children were treated in a University setting from April to June 2019. Results Both solutions had similar anaesthetic efficacy in primary molar extraction when applied by the infiltrative technique (β −0.47; 95% CI −3.19 to 2.24; P = .76); however, children reported higher mean pain during articaine deposition (β 2.43; 95% CI 0.28‐4.57; P = .02). The measured lidocaine pH was 3.19 (0.15) and articaine was 2.43 (0.00) ( P = .04). Post‐operative pain, oedema and nausea were observed without differences between the groups. Conclusions There was no difference in the efficacy of articaine compared to lidocaine for primary molar extraction. Articaine was more painful during the injection. Practical implications Primary molar extractions can be performed with both articaine and lidocaine buccal infiltration.