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Relationship between arthroscopic findings of synovitis and levels of tumour necrosis factor‐alpha and matrix metalloproteinases in synovial lavage fluid from patients with unilateral high mandibular condyle fractures
Author(s) -
Nogami S.,
Takahashi T.,
Yamauchi K.,
Takeda Y.,
Ito K.,
Chiba M.,
Gaggl A.
Publication year - 2018
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/joor.12632
Subject(s) - medicine , synovitis , arthrocentesis , temporomandibular joint , arthroscopy , synovial fluid , condyle , matrix metalloproteinase , surgery , gastroenterology , osteoarthritis , dentistry , pathology , arthritis , alternative medicine
Summary Arthrocentesis has an effect of washing out inflammatory products that accumulate in the joint compartment of a dysfunctional temporomandibular joint ( TMJ ). The procedure removes inflammatory cytokines, which are pain‐causing substances, for early reduction of TMJ pain and quick recovery of jaw function, thus increasing the possibility of a successful rehabilitation. The aim of this study was to investigate the relationship between arthroscopy synovitis grade in patients with unilateral high condylar fractures and concentrations of the pro‐inflammatory cytokines tumour necrosis factor ( TNF )‐alpha as well as of matrix metalloproteinases ( MMP s) in washed‐out synovial fluid ( SF ) samples obtained from those patients. A total of 26 patients with unilateral high condylar fractures who underwent arthrocentesis for a therapeutic purpose were examined. SF samples were collected before performing arthroscopy to determine synovitis grade. The detection rates and concentrations of TNF ‐alpha and MMP s were determined, and their association with synovitis grade was analysed. TNF ‐alpha was detected in 23 and MMP ‐3 in 22 of the TMJ s. There was a correlation between synovitis grade and concentration of TNF ‐alpha in the fracture group. Furthermore, the concentrations of TNF ‐alpha and MMP ‐3 were significantly higher as compared to the control group, comprised of TMJ s on the non‐fracture side of the same patients, while a correlation was also noted between TNF ‐alpha concentration and synovitis grade in the fracture group. The present findings may provide a biological/biochemical rationale for arthrocentesis as a reasonable treatment modality for high condylar fractures.