Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders

Summary The synovial membrane and fluid are significantly involved in the pathogenesis of temporomandibular joint ( TMJ ) disorders. This study aimed to investigate the relation between levels of chemerin in the synovial fluid ( SF ) of patients with TMJ disorder and their relationship. Sixty samples of SF were obtained from patients with an internal derangement ( ID ) or osteoarthritis ( OA ). Chemerin in the SF was examined by enzyme‐linked immunosorbent assay ( ELISA ). The results showed greater levels of chemerin in the SF of patients with OA than ID . While chemerin levels were positively correlated with pain scores, they were inversely correlated with MMO . Chemerin levels increased progressively as the disorder stage became more severe. The findings of this study suggest that chemerin in SF may play role as a predisposing factor and may represent a novel potential prognostic biochemical marker in the pathogenesis of TMJ disorders.