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Expression of chemerin in the synovial fluid of patients with temporomandibular joint disorders
Author(s) -
Şimşek Kaya G.,
Yapıcı Yavuz G.,
Kızıltunç A.
Publication year - 2018
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/joor.12608
Subject(s) - chemerin , pathogenesis , synovial fluid , osteoarthritis , medicine , temporomandibular joint , temporomandibular disorder , temporomandibular joint disorder , endocrinology , gastroenterology , pathology , adipokine , insulin resistance , alternative medicine , insulin
Summary The synovial membrane and fluid are significantly involved in the pathogenesis of temporomandibular joint ( TMJ ) disorders. This study aimed to investigate the relation between levels of chemerin in the synovial fluid ( SF ) of patients with TMJ disorder and their relationship. Sixty samples of SF were obtained from patients with an internal derangement ( ID ) or osteoarthritis ( OA ). Chemerin in the SF was examined by enzyme‐linked immunosorbent assay ( ELISA ). The results showed greater levels of chemerin in the SF of patients with OA than ID . While chemerin levels were positively correlated with pain scores, they were inversely correlated with MMO . Chemerin levels increased progressively as the disorder stage became more severe. The findings of this study suggest that chemerin in SF may play role as a predisposing factor and may represent a novel potential prognostic biochemical marker in the pathogenesis of TMJ disorders.