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Influence of intramuscular granisetron on experimentally induced muscle pain by acidic saline
Author(s) -
Louca S.,
Ernberg M.,
Christidis N.
Publication year - 2013
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/joor.12046
Subject(s) - saline , anesthesia , medicine , placebo , masseter muscle , granisetron , intramuscular injection , isotonic saline , nausea , anatomy , antiemetic , alternative medicine , pathology
Summary The aim of this study was to investigate whether intramuscular administration of the 5‐ HT 3 receptor antagonist granisetron reduces experimental muscle pain induced by repeated intramuscular injections of acidic saline into the masseter muscles. Twenty‐eight healthy and pain‐free volunteers, fourteen women and fourteen men participated in this randomized, double‐blind and placebo‐controlled study. After a screening examination and registration of the baseline pressure–pain threshold ( PPT ), the first simultaneous bilateral injections of 0·5 mL acidic saline (9 mg mL −1 , pH 3·3) into the masseter muscles were performed. Two days later, PPT and pain ( VAS ) were re‐assessed. The masseter muscle was then pre‐treated with 0·5 mL granisetron (Kytril ® 1 mg mL −1 pH 5·3) on one side and control substance (isotonic saline, 9 mg mL −1 pH 6) on the contralateral side. Two minutes thereafter a bilateral simultaneous injection of 0·5 mL acidic saline followed. The evoked pain intensity, pain duration, pain area and PPT were assessed. The volunteers returned 1 week later to re‐assess VAS and PPT . On the side pre‐treated with granisetron, the induced pain had significantly lower intensity and shorter duration ( P < 0·05) compared with the side pre‐treated with control. A subgroup analysis showed that the effect of granisetron on pain duration was significant only in women ( P < 0·001), while the effect on peak pain and pain area were significant in both sexes. The results showed no significant change in PPT . In conclusion, these results indicate that granisetron has a pain‐reducing effect on experimentally induced muscle pain by repeated acidic saline injection.