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A randomised titrated crossover study comparing two oral appliances in the treatment for mild to moderate obstructive sleep apnoea/hypopnoea syndrome
Author(s) -
Zhou J.,
Liu Y.H.
Publication year - 2012
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1111/joor.12006
Subject(s) - medicine , crossover study , airway , oral appliance , analysis of variance , anesthesia , randomized controlled trial , repeated measures design , dentistry , confidence interval , sleep (system call) , obstructive sleep apnea , surgery , mathematics , statistics , alternative medicine , pathology , computer science , placebo , operating system
Summary The objective of this study was to compare the efficiency of two oral appliances in patients with mild to moderate obstructive sleep apnoea/hypopnoea syndrome ( OSAHS ) by the analysis of objective and subjective evaluations and measurement of upper airway parameter. A randomised crossover design trial was carried out on 16 patients with OSAHS . Two different types of oral appliances were tested in each patient, a one‐piece monoblock and the SILENT NITE ® ( G lide W ell L aboratories, N ewport B each, CA, USA), a two‐piece appliance. Each oral appliance needed to be worn for two 3‐month periods separated by a 2‐week wash‐out period in between. The objective and subjective efficiency and upper airway parameters associated with the oral appliances were assessed. One‐way analysis of variance ( anova ) test was performed to compare the changes in upper airway morphology and the treatment efficiency between the appliances. The monoblock and SILENT NITE ® (GlideWell Laboratories) appliances reduced A pnoea H ypopnoea I ndex ( AHI ) from 26·38 ± 4·13 to 7·58 ± 2·28 ( P < 0·001) and 8·87 ± 2·88 ( P < 0·001), respectively. The monoblock appliance was statistically more efficient in reducing AHI and Apnoea Index ( AI ) than the SILENT NITE ® (GlideWell Laboratories) ( P < 0·05). The scores on E pworth's S leepiness S cale ( ESS ) and S noring S cale ( SS ) were improved significantly by both appliances. The upper airway spaces showed considerable enlargement by both mandibular advancement appliances ( MAA s) ( P < 0·05), while no significant differences were found between the two appliances ( P > 0·05). Both MAA s showed good efficacy in the treatment for mild to moderate OSAHS . Use of the monoblock appliance should be considered when patients with OSAHS choose MAA treatment, as it was more efficient in reducing the AHI and AI compared to the two‐piece appliance and was preferred by most patients. Long‐term efficiency should be evaluated in future prospective studies.