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Periventricular White Matter Hyperintensities on MRI: Correlation With Neuropathologic Findings
Author(s) -
Smith Charles D.,
Snowdon David,
Markesbery William R.
Publication year - 2000
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon200010113
Subject(s) - hyperintensity , white matter , medicine , magnetic resonance imaging , pathology , myelin , radiology , central nervous system
Periventricular white matter hyperintensities on postmortem magnetic resonance imaging (MRI) and myelin‐stained frontal and parietal histologic sections were evaluated independently in 12 cases. There was a strong relationship between the extent of white matter hyperintensities on MRI and the extent of gross and microscopic changes seen in the white matter of myelinstained sections, particularly in the frontal lobe. In this material, the extent of myelin rarefaction correlated with a 0‐ to 8‐point white matter hyperintensity scale rating on MRI in the same brains.