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Neuroimaging Findings in a Patient Recovering from Global Alexia to Spelling Dyslexia
Author(s) -
Lanzinger S,
Weder B,
Oettli R,
Fretz C
Publication year - 1999
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon19999148
Subject(s) - dyslexia , medicine , agraphia , neuroimaging , spelling , basal (medicine) , temporal lobe , posterior cerebral artery , posterior cortical atrophy , infarction , audiology , forceps , middle cerebral artery , ischemia , cardiology , pathology , psychiatry , epilepsy , surgery , reading (process) , philosophy , law , dementia , linguistics , myocardial infarction , political science , disease , insulin
The authors report findings in a 67‐year‐old right‐handed man who had an ischemic infarct in the territory of the left posterior cerebral artery. The clinical manifestation consisted mainly of total alexia without agraphia. The patient gradually recovered, subsequently showing the syndrome of spelling dyslexia. Cerebral MR‐images revealed a circumscript infarction of medial and basal parts of left temporal lobe. In the acute stage [ 99m Tc]HMPAO SPECT was characterized by a diminished uptake in the definitely infarcted area and hyperfixation in the region of the left forceps major. Because high retention of HM‐PAO indicates potentially salvageable tissue after an ischemic event, the depicted area might be correlated with the recovery of function. Thus, the authors' neuroimaging data give further support to the assumption that the left forceps major is a critical area for global alexia, whereas spelling dyslexia is due to involvement of the left medio‐basal temporal lobe.