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Age‐Related Changes of the Insular Cortex and Lateral Ventricles: Conventional MRI Volumetric Measures
Author(s) -
Foundas Anne L.,
Zipin Debra,
Browning Cassandra A.
Publication year - 1998
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199884216
Subject(s) - lateral ventricles , insular cortex , medicine , cerebral ventricle , magnetic resonance imaging , ventricle , insula , cerebrospinal fluid , cortex (anatomy) , anatomy , left ventricles , cardiology , radiology , neuroscience , psychology , psychiatry
Preliminary data suggest that the insular region may be atrophied in patients with Alzheimer's disease when compared with healthy, age‐matched control subjects. Therefore, normative data on age‐related changes of the insular cortex were gathered and compared with age‐related changes in the bodies of the lateral ventricles, which have been studied previously Cerebrospinal fluid (CSF) volume of the lateral ventricles and insular cortical regions were measured on T1‐weighted axial magnetic resonance images in 93 healthy subjects (age, 21 to 84 years). Age‐related changes were found in the lateral ventricles (r = 0.57, p < 0.0001) and in the CSF insular space (r = 0.42, p < 0.0001). Increasing age accounted for a significant amount of the variance for the lateral ventricle (pc = 0.45, p < 0.0001), but not for the insula (pc = 0.15, p = 0.14). Although there was a continuous linear increase in lateral ventricular volume with age, the CSF insular space increased linearly until the fourth decade, then plateaued until the seventh decade, with a linear increase thereafter. These data suggest that age‐related changes occur in the region of the insular cortex, but differ from age‐related changes of the lateral ventricles.