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Extensive Reversible Brain Magnetic Resonance Lesions in a Patient with HELLP Syndrome
Author(s) -
Feske Steven K.,
Sperling Reisa A.,
Schwartz Richard B.
Publication year - 1997
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199774247
Subject(s) - hellp syndrome , medicine , posterior reversible encephalopathy syndrome , magnetic resonance imaging , encephalopathy , hypertensive encephalopathy , eclampsia , pathogenesis , preeclampsia , edema , pregnancy , pathology , cardiology , radiology , genetics , blood pressure , biology
A severe form of toxemia of pregnancy with microangiopathic hemolytic anemia, elevated /iver enzymes, and /ow platelets has been called the HELLP syndrome. A patient with the HELLP syndrome developed a severe, reversible encephalopathy. Brain computed tomography and magnetic resonance imaging showed abnormalities consistent with edema limited to the posterior circulation territory. The location of the lesions and their occurrence in the HELLP syndrome support suggestions that the vulnerability of posterior structures in eclamptic encephalopathy is due to a vascular susceptibility of the posterior circulation and that endothelial cell dysfunction plays an important role in the pathogenesis of eclamptic encephalopathy.