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Quantified Volumes of Temporal Lobe Structures in Patients with Epilepsy
Author(s) -
Breier Joshua I.,
Leonard Christiana M.,
Bauer Russell M.,
Roper Steven,
Lucas Timothy H.,
Gilmore Robin L.
Publication year - 1996
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199662108
Subject(s) - temporal lobe , epilepsy , medicine , white matter , magnetic resonance imaging , thresholding , atrophy , focus (optics) , audiology , nuclear medicine , neuroscience , radiology , pathology , artificial intelligence , psychology , psychiatry , computer science , physics , image (mathematics) , optics
The T1‐weighted volumetric magnetic resonance images of 31 patients with intractable temporal lobe epilepsy, and 13 control subjects matched for age and sex, were subjected to semiautomated threshold analysis. The method used proved to be relatively fast and reliable. An index of temporal lobe interhemispheric asymmetry was extracted by thresholding high‐signal (white matter) pixels. Patients had significantly more asymmetrical indices for white matter and hippocampal volumes than did control subjects, and the two indices were significantly correlated, providing evidence for the validity of the white matter index. Differences in both indices were consistent with decreased tissue on the side of the focus. In classification analyses a combination of these two indices correctly predicted the side of focus at a greater rate than did either used alone. Findings provide support for the hypothesis that seizure activity is associated with atrophy in both mesial and lateral temporal lobe structures.