Premium
Functional Caudate Imaging in Symptomatic Huntington's Disease: Positron Emission Tomography Versus SinglePhoton Emission Computed Tomography
Author(s) -
Martin W. R. W.,
Hoskinson M.,
Kremer B.,
Maguire C.,
McEwan A.
Publication year - 1995
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199554227
Subject(s) - positron emission tomography , medicine , single photon emission computed tomography , emission computed tomography , caudate nucleus , neuroimaging , nuclear medicine , cerebral blood flow , brain positron emission tomography , positron emission , preclinical imaging , tomography , radiology , in vivo , psychiatry , microbiology and biotechnology , biology
Functional neuroimaging with positron emission tomography previously demonstrated reduced caudate glucose metabolism in virtually all symptomatic patients with Huntington's disease (HD) Single‐photon emission computed tomography studies of brain blood flow also have shown caudate abnormalities in patients with HD. The present study compared these two functional imaging modalities in 6 patients with HD who had been symptomatic for fewer than 5 years. All patients had significantly impaired caudate‐thalamus and caudate‐whole‐slice glucose metabolism ratios as measured by positron emission tomography. However, only 3 had clearly abnormal caudate‐thalamus activity ratios and 2 had clearly abnormal caudate‐whole‐slice ratios on single‐photon emission computed tomography. These findings indicate that single‐photon emission computed tomography imaging of caudate blood flow is a less sensitive indicator of caudate dysfunction in early HD than is positron emission tomography imaging of caudate glucose metabol1sm.