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Localized In Vivo 1 H Magnetic Resonance Spectroscopy and In Vitro Analyses of Heterogeneous Brain Tumors
Author(s) -
Chang Linda,
McBride Duncan,
Miller Bruce L.,
Cornford Marsha,
Booth Ruth A.,
Buchthal Steven D.,
Ernst Thomas M.,
Jenden Donald
Publication year - 1995
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199553157
Subject(s) - in vivo , choline , creatine , magnetic resonance imaging , pathology , in vitro , medicine , in vivo magnetic resonance spectroscopy , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , histology , brain tumor , nuclear medicine , biochemistry , chemistry , biology , radiology , physics , microbiology and biotechnology
Results of magnetic resonance spectroscopic (MRS) studies of the chemical patterns in brain tumors have been mconsistent. Actual biochemical correlations are needed. In 2 patients with heterogeneous intracranial tumors, in vivo 1 H MRS and in vitro biochemical analyses were correlated. Histology confirmed the tumor heterogeneity. Choline was elevated in the cellular portion of both tumors but decreased in the necrotic or cystic portions. Creatine was diffusely decreased while lactate was elevated in all regions of both tumors. Furthermore, the increase in the choline peak on 1 H MRS appeared to be due to increases in water‐soluble choline compounds. This study illustrates the value of small localized voxels for differentiating regional chemical differences in tumors.