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In Vivo Proton Spectroscopy of Intracranial Infections and Neoplasms
Author(s) -
Yamagata Nelson T,
Miller Bruce L,
McBride Duncan,
Chang Linda,
Chiang Francis,
Nikas Diana,
Osborne Diane,
Buchthal Steven D
Publication year - 1994
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon19944123
Subject(s) - choline , phosphocreatine , creatine , medicine , in vivo , nuclear magnetic resonance spectroscopy , pathology , in vivo magnetic resonance spectroscopy , magnetic resonance imaging , leukoencephalopathy , nuclear magnetic resonance , nuclear medicine , biology , radiology , physics , microbiology and biotechnology , disease , energy metabolism
The chemical characteristics of 10 neoplastic and 11 infectious brain masses were studied by in vivo 1 H magnetic resonance spectroscopy. In tumors, peak height ratios of n ‐acetyl‐L‐aspartate to choline were decreased compared to those in normal brain tissue and infectious masses ( p < 0.02), but the ratios in normal brains and those with infections did not differ. N ‐acetyl‐L‐aspartate—to‐creatine/phosphocreatine ratios were significantly lower in infectious masses and tumors compared to normal brain tissue ( p = 0.003). However, in progressive multifocal leukoencephalopathy, N ‐acetyl‐L‐aspartate appeared relatively unchanged. Lactate was greater than choline in 9 of 11 brains with infection, 0 of 14 control brains, and 1 of 10 tumors. Lactate‐to‐choline ratios were significantly elevated in infectious masses compared with tumors ( p < 0.01). 1 H magnetic resonance spectroscopy is promising for the noninvasive diagnosis of focal brain masses.