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Striatal Glucose Metabolism and Pattern of Cerebral Regional Interactions in Choreic Disorders
Author(s) -
Pietrini P.,
Azari N. P.,
Pettigrew K. D.,
Horwitz B.,
Kozachuk W.,
Kumar A.,
Salerno J.,
Grady C. L.,
Haxby J. V.,
Aronin N.,
Marshall P.,
Schapiro M. B.
Publication year - 1993
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199333151
Subject(s) - chorea , positron emission tomography , medicine , choreiform movement , striatum , dementia , movement disorders , neuroscience , nuclear medicine , endocrinology , disease , parkinson's disease , dyskinesia , psychology , dopamine
With positron emission tomography (PET), cerebral glucose metabolism was studied in 5 patients with familial inverted chorea, a progressive choreiform disease with no dementia, and in age‐ and sex‐matched control subjects. Computed tomography scans excluded cortical or striatal atrophy. PET scans showed no group differences in striatal glucose metabolism. However, when a discriminant analysis method was applied to the PET metabolic data, a discriminant function, reflecting functional interactions involving the striatum, successfully distinguished the patients from the control subjects. These results indicate striatal involvement in the pathophysiology of familial inverted chorea, and emphasize the importance of alternative methods of analyzing regional PET data.