Premium
Continuous Blood Flow Velocity Measurements in Obstructive Sleep Apnea Syndrome
Author(s) -
Rieke Klaus,
Poceta J. Steven,
Mitler Merrill M.,
Ley Larry R.,
Torruella Ann K.,
Adams Hans-Peter,
Otis Shirley M.
Publication year - 1992
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199224202
Subject(s) - medicine , transcranial doppler , cerebral blood flow , blood flow , middle cerebral artery , apnea , continuous positive airway pressure , anesthesia , obstructive sleep apnea , cardiology , magnetic resonance imaging , flow velocity , blood pressure , ischemia , radiology , relaxation (psychology)
Mean blood flow velocity was measured by transcranial Doppler (TCD) sonography in 15 patients with obstructive sleep apnea syndrome. Relative increases of mean flow velocity in the middle cerebral artery (MCA) during apneas were seen in all patients, and were related to the severity of desaturation ( p < 0.05). Additionally, a relationship between mean flow velocity and both end‐tidal carbon dioxide pressure and oxyhemoglobin desaturation could be demonstrated, suggesting that cerebral blood flow is regulated by both parameters. After patients were treated with nasal continuous positive airway pressure, the mean flow velocity was normalized, demonstrating a beneficial effect of this treatment. Magnetic resonance imaging of the brain demonstrated abnormalities in 2 patients, raising the possibility that daytime neuronal dysfunction in sleep apnea patients may relate to increased mean flow velocity with secondary microvascular damage.