Premium
Medial Temporal Atrophy as a Magnetic Resonance Imaging Marker for Alzheimer's Disease
Author(s) -
Barclay Laurie L,
Linden Craig,
Murtagh Reed
Publication year - 1992
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199223131
Subject(s) - medicine , magnetic resonance imaging , dementia , atrophy , pathology , alzheimer's disease , temporal lobe , vascular dementia , neuroscience , autopsy , disease , dementia with lewy bodies , neuroimaging , radiology , biology , psychiatry , epilepsy
Medial temporal lobe atrophy (MTLA) on brain magnetic resonance imaging (MRI) may help differentiate Alzheimer's disease (AD) from multiinfarct dementia (MID) and other dementias. MTLA was seen in 6 of 11 patients with clinically diagnosed AD, 16 of 20 with mixed dementia (with both AD and MID), 1 of 5 with psychiatric disease, and in none of 32 with MID or 8 with other dementias ( p < 0.0001 ). Increased patchy periventricular signal, or “unidentified bright objects” were seen in 2 of 11 patients with AD, 10 of 20 patients with AD and MID, and 26 of 32 patients with MID. A larger series with autopsy correlation may verify that MTLA is a reasonably specific marker for AD, and unidentified bright objects are a sensitive, but not specific, marker for vascular dementias.