Medial Temporal Atrophy as a Magnetic Resonance Imaging Marker for Alzheimer's Disease | Zendy

Barclay Laurie L | Zendy; Linden Craig | Zendy; Murtagh Reed | Zendy

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Medial Temporal Atrophy as a Magnetic Resonance Imaging Marker for Alzheimer's Disease

Author(s) -

Barclay Laurie L,

Linden Craig,

Murtagh Reed

Publication year - 1992

Publication title -

journal of neuroimaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.822

H-Index - 64

eISSN - 1552-6569

pISSN - 1051-2284

DOI - 10.1111/jon199223131

Subject(s) - medicine , magnetic resonance imaging , dementia , atrophy , pathology , alzheimer's disease , temporal lobe , vascular dementia , neuroscience , autopsy , disease , dementia with lewy bodies , neuroimaging , radiology , biology , psychiatry , epilepsy

Medial temporal lobe atrophy (MTLA) on brain magnetic resonance imaging (MRI) may help differentiate Alzheimer's disease (AD) from multiinfarct dementia (MID) and other dementias. MTLA was seen in 6 of 11 patients with clinically diagnosed AD, 16 of 20 with mixed dementia (with both AD and MID), 1 of 5 with psychiatric disease, and in none of 32 with MID or 8 with other dementias ( p < 0.0001 ). Increased patchy periventricular signal, or “unidentified bright objects” were seen in 2 of 11 patients with AD, 10 of 20 patients with AD and MID, and 26 of 32 patients with MID. A larger series with autopsy correlation may verify that MTLA is a reasonably specific marker for AD, and unidentified bright objects are a sensitive, but not specific, marker for vascular dementias.

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