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Single‐Photon Emission Computed Tomography Studies of Regional Cerebral Blood Flow in Multiple Infarct Dementia
Author(s) -
Eberling Jamie L.,
Jagust William J.,
Reed Bruce R.,
KwoonYuen P. F.,
Martin Eileen M.
Publication year - 1992
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon19922279
Subject(s) - cerebral blood flow , medicine , dementia , single photon emission computed tomography , emission computed tomography , perfusion , positron emission tomography , temporal cortex , posterior parietal cortex , blood flow , cardiology , alzheimer's disease , hemodynamics , neuroscience , nuclear medicine , disease , psychology
Multiinfarct dementia (MID) and Alzheimer's disease (AD), both characterized by a decline in cognitive function, are often difficult to differentiate and may coexist. This study reports the findings of single‐photon emission computed tomography (SPECT) using [ 231 ] N ‐isopropyl‐ p ‐iodoamphetamine to determine cerebral blood flow patterns in patients with MID (n = 11 ), as compared with patients with AD (n = 22) and nondemented control subjects (n = 12). Data were acquired at two tomographic levels for dorsolateral frontal, parietal, orbitofrontal, and temporal areas of the cortex. Analyses of variance revealed that the blood flow pattern for the MID group was very similar to that in the AD patients, with both groups showing hypoperfusion in the temporal area, although blood flow in the left parietal region was lower for the patients with AD. When normal regional cerebral blood flow (rCBF) was defined as within 2 standard deviations of control values, most of the patients with MID had normal rCBF, while a few patients showed abnormal rCBF in all regions. In contrast, the majority of AD patients showed abnormal rCBF in the temporal part of the cortex. This suggests that while AD is characterized by hypoperfusion in the temporal and parietal areas, there is no characteristic rCBF pattern in MID. These findings emphasize the need to use multiple modalities when clinically evaluating patients with MID.