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Methotrexate‐induced Leukoencephalopathy
Author(s) -
Kibria Eshan
Publication year - 1992
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon199222111
Subject(s) - medicine , leukoencephalopathy , methotrexate , magnetic resonance imaging , antifolate , lymphoblastic leukemia , leukemia , pharmacology , radiology , antimetabolite
Methotrexate, a folic acid antagonist, is commonly administered intrathecally or intravenously as part of treatment of acute lymphoblastic leukemia, brain tumor, or childhood osteosarcoma. It is well documented that intrathecal administration of methotrexate combined with radiation therapy causes leukoencephalopathy; however, there are no reports on the effects of methotrexate administered intravenously without radiation. A child with acute lymphoblastic leukemia was given intravenous methotrexate and subsequently developed clinical signs and magnetic resonance imaging findings consistent with leukoencephalopathy.