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Diffusion tensor imaging reveals greater microstructure damage in lesional tissue that shrinks into cerebrospinal fluid in multiple sclerosis
Author(s) -
Bergsland Niels,
Dwyer Michael G.,
Jakimovski Dejan,
WeinstockGuttman Bianca,
Zivadinov Robert
Publication year - 2021
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12891
Subject(s) - medicine , diffusion mri , lesion , multiple sclerosis , cerebrospinal fluid , atrophy , fractional anisotropy , magnetic resonance imaging , pathology , radiology , psychiatry
Background and Purpose Atrophied T2 lesion volume (LV), reflecting the complete transformation of lesions into cerebrospinal fluid (CSF), has been associated with disease progression in multiple sclerosis (MS). The underlying damage leading to lesion destruction remains poorly understood. The objective of this study was to use diffusion tensor imaging (DTI) to investigate the extent of microstructural tissue damage at baseline in lesions that subsequently transform into CSF. Methods Ninety‐nine MS patients (67 relapsing‐remitting MS [RRMS] and 32 progressive PMS [PMS]) were imaged at baseline and after an average of 5.3 ± 0.6 years of follow‐up. Assessments included T2 LV and DTI at baseline and atrophied T2 LV over follow‐up. Lesioned areas that became atrophied T2 LV were compared to those that did not. Baseline lesional DTI metrics were compared between RRMS versus PMS patients and between patients with disability progression (DP, n = 35) versus non‐DP ( n = 64), using ANCOVA models. Results Lesion tissue that developed into atrophied T2 LV had significantly different baseline DTI parameters compared to nonatrophied T2‐LV tissue ( p <0.001), with the largest effect for free‐water ( d = 2.739). Baseline tissue characteristics of future atrophied T2 LV were not significantly different between groups. However, DP patients developed greater atrophied T2 LV (377 vs. 83 mm 3 , p < 0.001). Conclusions Extensive microstructural damage characterizes lesions replaced by CSF, independently of disease phenotype or future DP. Greater atrophied T2 LV predicts DP.