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Altered Structural Brain Networks Related to Adrenergic/Muscarinic Receptor Autoantibodies in Chronic Fatigue Syndrome
Author(s) -
Fujii Hiroyuki,
Sato Wakiro,
Kimura Yukio,
Matsuda Hiroshi,
Ota Miho,
Maikusa Norihide,
Suzuki Fumio,
Amano Keiko,
Shin Isu,
Yamamura Takashi,
Mori Harushi,
Sato Noriko
Publication year - 2020
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12751
Subject(s) - medicine , white matter , muscarinic acetylcholine receptor , autoantibody , neuroscience , betweenness centrality , cardiology , receptor , magnetic resonance imaging , immunology , psychology , centrality , antibody , radiology , mathematics , combinatorics
BACKGROUND AND PURPOSE Recent studies suggest that the autoantibodies against adrenergic/muscarinic receptors might be one of the causes and potential markers of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The purpose of this study was to investigate the structural network changes related to autoantibody titers against adrenergic/muscarinic receptors in ME/CFS by performing a single‐subject gray matter similarity‐based structural network analysis. METHODS We prospectively examined 89 consecutive right‐handed ME/CFS patients who underwent both brain MRI including 3D T1‐wighted images and a blood analysis of autoantibodies titers against β1 adrenergic receptor (β1 AdR‐Ab), β2 AdR‐Ab, M3 acetylcholine receptor (M3 AchR‐Ab), and M4 AchR‐Ab. Single‐subject gray matter similarity‐based structural networks were extracted from segmented gray matter images for each patient. We calculated local network properties (betweenness centrality, clustering coefficient, and characteristic path length) and global network properties (normalized path length λ, normalized clustering coefficient γ, and small‐world network value δ). We investigated the correlations between the autoantibody titers and regional gray matter/white matter volumes, the local network properties, and the global network properties. RESULTS Betweenness centrality showed a significant positive correlation with β1‐AdR‐Ab in the right dorsolateral prefrontal cortex. The characteristic path length showed a significant negative correlation with β2‐AdR‐Ab in the right precentral gyrus. There were no significant correlations between the antibody titers and the regional gray matter/white matter volumes, and the global network properties. CONCLUSIONS Our findings suggest that β1 AdR‐Ab and β2 AdR‐Ab are potential markers of ME/CFS.