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Vagus Nerve Ultrasound in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Charcot‐Marie‐Tooth Disease Type 1A
Author(s) -
Niu Jingwen,
Zhang Lei,
Ding Qingyun,
Liu Jingwen,
Zhang Zhe,
Cui Liying,
Liu Mingsheng
Publication year - 2020
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12747
Subject(s) - medicine , vagus nerve , polyradiculoneuropathy , ulnar nerve , vagus nerve stimulation , anesthesia , surgery , guillain barre syndrome , elbow , pediatrics , stimulation
BACKGROUND AND PURPOSE Both clinical autonomic dysfunction and involvement of autonomic nerves have been reported in a range of peripheral nerve disorders. We employed nerve ultrasound to assess the size of the vagus nerve in a serial study of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Charcot‐Marie‐Tooth type 1B (CMT1B) as compared to healthy controls (HCs). We correlated these findings with involvement of the median and ulnar nerves. METHODS Forty‐three patients with CIDP, 8 with CMT1A, and 105 HC were prospectively recruited. The cross‐sectional areas (CSAs) of the vagus, median, and ulnar nerves were measured bilaterally. The alteration of CSA of those nerves was followed longitudinally in CIDP. RESULTS The median (range) CSA of the vagus nerve was 2 (1‐28) mm 2 in CIDP, 3 (2‐6) mm 2 in CMT1A, and 1 (1‐2) mm 2 in HC. The vagus nerve CSA was positively correlated with the maximum CSA of median/ulnar nerve in CIDP and CMT1A. The alteration in vagus nerve CSA was positively correlated with the alteration in mean median/ulnar nerve CSA in CIDP during follow‐up. CONCLUSIONS The vagus nerve was involved to a similar extent as the median and ulnar nerves in CIDP and CMT1A, although no symptoms or signs of vagus nerve involvement were found. Further study should be performed to explore the clinical relevance of vagus nerve enlargement in these disorders.