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The Association between Whole‐Brain MR Spectroscopy and IDH Mutation Status in Gliomas
Author(s) -
Goryawala Mohammed,
SarafLavi Efrat,
Nagornaya Natalia,
Heros Deborah,
Komotar Ricardo,
Maudsley Andrew A.
Publication year - 2019
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12685
Subject(s) - isocitrate dehydrogenase , glioma , idh1 , metabolite , medicine , glutamine , mutant , wild type , creatine , in vivo magnetic resonance spectroscopy , choline , white matter , nuclear medicine , pathology , magnetic resonance imaging , cancer research , biology , genetics , biochemistry , amino acid , gene , radiology , enzyme
BACKGROUND AND PURPOSE Mutations in isocitrate dehydrogenase (IDH) have a direct effect on gliomagenesis. The purpose of this study is to quantify differences in brain metabolites due to IDH mutations. METHODS Magnetic Resonance Spectroscopic Imaging (MRSI) was performed in 35 patients with gliomas of different grade and varied IDH mutation status. Volumes of interest (VOIs) for active tumor (tVOI), peritumoral area (pVOI), and contralateral normal‐appearing white matter (cVOI) were created. Metabolite ratios of Choline (Cho) to both N ‐acetylaspartate (NAA) and Creatine (Cr) were estimated. Ratios of Glutamate/Glutamine complex (Glx) and myoinositol (mIno) to Cr were also quantified. General linear models (GLMs) were used to estimate the effects of IDH mutation on metabolite measures, with age, gender, and tumor grade used as covariates. RESULTS GLM analysis showed that maximum Cho/NAA and Cho/Cr in the tVOI were significantly ( P < .05) higher in IDH mutant lesions as compared to wild‐type. In the pVOI, mean Cho/Cr was found to be significantly different among IDH mutant and wild‐type gliomas. Mean Cho/NAA ( P = .306) and Cho/Cr ( P = .292) within the tVOI were not significantly different. Ratios of Glx/Cr and mIno/Cr in any region showed no significant differences between IDH mutant and wild‐type gliomas. No significant differences in metabolite ratios were seen in the cVOI between IDH mutants and wild‐types. CONCLUSION IDH mutation's effect in gliomas show an increase in Cho in the tumor and perilesional regions as compared to wild‐type lesions but do not show widespread changes across the brain.