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Myelin Water Fraction and Intra/Extracellular Water Geometric Mean T 2 Normative Atlases for the Cervical Spinal Cord from 3T MRI
Author(s) -
Liu Hanwen,
Ljungberg Emil,
Dvorak Adam V.,
Lee Lisa Eunyoung,
Yik Jackie T.,
MacMillan Erin L.,
Barlow Laura,
Li David K.B.,
Traboulsee Anthony,
Kolind Shan H.,
Kramer John L.K.,
Laule Cornelia
Publication year - 2019
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12659
Subject(s) - spinal cord , medicine , multiple sclerosis , myelin , population , anatomy , nuclear medicine , central nervous system , environmental health , psychiatry
Acquiring and interpreting quantitative myelin-specific MRI data at an individual level is challenging because of technical difficulties and natural myelin variation in the population. To overcome these challenges, we used multiecho T 2 myelin water imaging (MWI) to create T 2 metric healthy population atlases that depict the mean and variation of myelin water fraction (MWF), and intra- and extracellular water mobility as described by geometric mean T 2 (IEGMT 2 ).