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Myelin Water Atlas: A Template for Myelin Distribution in the Brain
Author(s) -
Liu Hanwen,
Rubino Cristina,
Dvorak Adam V.,
Jarrett Michael,
Ljungberg Emil,
Vavasour Irene M.,
Lee Lisa Eunyoung,
Kolind Shan H.,
MacMillan Erin L.,
Traboulsee Anthony,
Lang Donna J.,
Rauscher Alexander,
Li David K.B.,
MacKay Alexander L.,
Boyd Lara A.,
Kramer John L.K.,
Laule Cornelia
Publication year - 2019
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12657
Subject(s) - myelin , multiple sclerosis , white matter , medicine , atlas (anatomy) , magnetic resonance imaging , population , brain atlas , expanded disability status scale , pathology , cartography , neuroscience , radiology , anatomy , biology , immunology , environmental health , central nervous system , geography
Myelin water imaging (MWI) is a magnetic resonance imaging technique that quantifies myelin in-vivo. Although MWI has been extensively applied to study myelin-related diseases in groups, clinical use in individual patients is challenging mainly due to population heterogeneity. The purpose of this study was twofold: (1) create a normative brain myelin water atlas depicting the population mean and regional variability of myelin content; and (2) apply the myelin atlas to assess the degree of demyelination in individuals with multiple sclerosis (MS).