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Arterial Spin Labeling MRI to Measure Cerebral Blood Flow in Untreated Ischemic Stroke
Author(s) -
Crisi Girolamo,
Filice Silvano,
Scoditti Umberto
Publication year - 2018
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12569
Subject(s) - medicine , cerebral blood flow , perfusion , diffusion mri , univariate analysis , magnetic resonance imaging , perfusion scanning , stroke (engine) , nuclear medicine , cardiology , radiology , multivariate analysis , mechanical engineering , engineering
BACKGROUND AND PURPOSE This study aims to investigate the significance of regional hyperperfusion (RH) detected by arterial spin labeling (ASL) in a group of untreated stroke patients, within 24‐36 hours after symptom onset. The relationship between RH volume and infarcted volume (DIV) as defined on diffusion weighted images (DWIs) was evaluated. METHODS Of the 346 consecutive acute stroke patients who attended our center, we retrospectively reviewed MRI studies of 47 patients who were ineligible for standard treatment with intravenous tissue plasminogen activator. The MRI study included ASL and DWI. The ASL‐derived cerebral blood flow (CBF) maps were coregistered on the DWI images. RH volume and DIV were calculated and compared. Patient NIHSS scores were also evaluated at admission, discharge, and after 1 and 6‐month follow‐up. RESULTS Twenty‐two patients showed RH with CBF twice than baseline. In all 22 patients, RH overlaps with DWI infarcted area. No significant difference ( P = .94) between RH volume and DIV was found (7.2 ± 9.6 and 9.0 ± 11.9 cm 3 ). The Pearson's correlation coefficient between RH and DIV was .93. On univariate analysis, a significant difference was found between patient's groups on NIHSS at any time points, after covariates adjustment NIHSS difference was significant only at admission. CONCLUSIONS The study showed that ASL perfusion could be an integral part of the MRI examination in the assessment of 24‐36 hours not‐treated stroke patients as sustained RH group had improved outcomes. More importantly, ASL perfusion may provide evidence of beneficial effects of reperfusion induced by recanalization treatment.