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Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis
Author(s) -
Cavallari Michele,
Egorova Svetlana,
Healy Brian C.,
Palotai Miklos,
Prieto Juan Carlos,
PolgarTurcsanyi Mariann,
Tauhid Shahamat,
Anderson Mark,
Glanz Bonnie,
Chitnis Tanuja,
Guttmann Charles R.G.
Publication year - 2017
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12490
Subject(s) - medicine , atrophy , multiple sclerosis , cohort , perivascular space , disease , magnetic resonance imaging , relapsing remitting , pathology , radiology , psychiatry
ABSTRACT BACKGROUND AND PURPOSE Enlarged perivascular spaces (EPVSs) have been associated with relapses and brain atrophy in multiple sclerosis (MS). We investigated the association of EPVS with clinical and MRI features of disease worsening in a well‐characterized cohort of relapsing‐remitting MS patients prospectively followed for up to 10 years. METHODS Baseline EPVSs were scored on 1.5T MRI in 30 converters to moderate‐severe disability, and 30 nonconverters matched for baseline characteristics. RESULTS EPVS scores were not significantly different between converters and nonconverters, nor associated with accrual of lesions or brain atrophy. CONCLUSIONS Our preliminary findings from a relatively small study sample argue against a potential use of EPVS as early indicator of risk for disease worsening in relapsing‐remitting MS patients in a clinical setting. Although the small sample size and clinical 1.5T MRI may have limited our ability to detect a significant effect, we provided estimates of the association of EPVS with clinical and MRI indicators of disease worsening in a well‐characterized cohort of MS patients.