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Spatial Coregistration of Functional Near‐Infrared Spectroscopy to Brain MRI
Author(s) -
Chen Michelle,
Blumen Helena M.,
Izzetoglu Meltem,
Holtzer Roee
Publication year - 2017
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12432
Subject(s) - functional near infrared spectroscopy , neuroimaging , medicine , functional magnetic resonance imaging , modality (human–computer interaction) , neuroscience , magnetic resonance imaging , computer science , artificial intelligence , prefrontal cortex , cognition , psychology , radiology
BACKGROUND AND PURPOSE Traditional neuroimaging techniques restrict movement and make it difficult to study the processes that require oral, upper limb, or lower limb motor execution. Functional near‐infrared spectroscopy (fNIRS) is an optical neuroimaging modality that measures brain oxygenation and permits movement during data acquisition. A key limitation of fNIRS, however, is the lack of a standard method to coregister quantitative fNIRS measurements to structural images such as magnetic resonance imaging (MRI). Additionally, fNIRS‐MRI coregistration studies have not been reported in older adults. METHODS fNIRS and structural MRI were acquired from 30 nondemented older adults. Sixteen fNIRS channels that assess hemodynamic changes in the prefrontal cortex (PFC; an area crucial in various age‐related processes) were coregistered to structural MRI. Vitamin E capsules were used to mark the locations of fNIRS detectors and light sources on the scalp. We used the balloon‐inflation algorithm to project fNIRS channel locations on the scalp to underlying cortical surface. RESULTS We provide coordinates for the 16 fNIRS channels in the PFC on the cortical surface in both MNI and Talairach spaces, with minimal variability that is within the spatial resolution of our fNIRS system. CONCLUSIONS Our study provides useful spatial information for stand‐alone fNIRS data in future studies, particularly investigations in age‐related processes.