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Cerebral Glucose Metabolism and Dopaminergic Function in Patients with Corticobasal Syndrome
Author(s) -
Mille Erik,
Levin Johannes,
Brendel Matthias,
Zach Christian,
Barthel Henryk,
Sabri Osama,
Bötzel Kai,
Bartenstein Peter,
Danek Adrian,
Rominger Axel
Publication year - 2016
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12391
Subject(s) - putamen , medicine , positron emission tomography , corticobasal degeneration , statistical parametric mapping , thalamus , basal ganglia , emission computed tomography , dopaminergic , cardiology , nuclear medicine , dementia , radiology , dopamine , magnetic resonance imaging , disease , central nervous system
BACKGROUND AND PURPOSE The corticobasal syndrome (CBS) is a clinical diagnosis that comprises a group of rare neurodegenerative diseases manifesting in movement disorder and cognitive impairment. While diagnosis is based upon clinical criteria, there have been a number of molecular imaging studies, albeit in rather small cohorts. Therefore, we investigated the pattern of cerebral glucose metabolism, as well as dopamine transporter (DAT) availability in a large and clinically well‐defined cohort. METHODS Thirty‐four patients fulfilling either the Armstrong or the Boeve criteria were assessed with [ 18 F]‐2‐fluoro‐2‐deoxy‐D‐glucose (FDG) positron emission tomography (PET) and/or [ 123 I]‐Ioflupane single‐photon‐emission‐computed tomography (SPECT) for DAT availability. A small subset of patients had also undergone D 2/3 receptor imaging. Imaging data were analyzed using both statistical parametric mapping and a volume‐of‐interest‐based approach relative to data from healthy controls. RESULTS Significant reductions of the cortical glucose metabolism were observed in the central region and the adjacent frontal and parietal association areas contralateral to the side with predominant motor symptoms. Reductions were also evident in the basal ganglia, notably in the putamen contralateral to the clinically affected side, and in the bilateral thalamus. DAT availability was reduced bilaterally, most distinctly on the side contralateral to the main motor symptoms. CONCLUSIONS We replicated and refined earlier findings of impaired glucose metabolism and nigrostriatal degeneration in CBS, highlighting asymmetric cortical and subcortical hypometabolism, symmetrically reduced metabolism in the thalamus, and only a slightly asymmetric reduction in DAT, while D 2/3 receptors seem to be mainly preserved. These results provide systematic evidence for the usefulness of FDG PET and dopaminergic SPECT imaging to characterize CBS.