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Fibrinolysis Treatment for Cerebral Intraventricular Hemorrhage: A Temporal and Spatial Voxel‐Based Analysis
Author(s) -
Strinitz Marc,
Kuramatsu Joji,
Kaschka Iris,
Kloska Stephan,
Dörfler Arnd,
Schwab Stefan,
Huttner Hagen B.,
Seifert Frank
Publication year - 2016
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12343
Subject(s) - medicine , intraventricular hemorrhage , ventricle , fibrinolysis , voxel , cerebral ventricle , third ventricle , intracerebral hemorrhage , cardiology , nuclear medicine , radiology , anesthesia , subarachnoid hemorrhage , gestational age , pregnancy , genetics , biology
ABSTRACT OBJECTIVE A voxel‐based statistical approach on computer tomographic data in patients with intracerebral hemorrhage (ICH) and acute intraventricular hemorrhage (IVH) was used to evaluate spatial and temporal patterns of intraventricular blood in patients treated with intraventricular fibrinolysis (IVF) or without. METHODS IVH shapes were systematically assessed three dimensionally in patients with supratentorial ICH at three intervals of time (day of admission, day 4 ± 1, day 7+). The boundaries of the intraventricular blood clot were delineated on computed tomography (CT) scans using dedicated software. The CT scan and the IVH shape were transferred into stereotaxic space. In a second step, voxel‐based statistics on group level were used to correlate the distribution of intraventricular blood with the interval and the treatment group. RESULTS Altogether 45 patients, 29 with IVF therapy and 16 without, were eligible to be included into this study. We found significant (false discovery rate [FDR] correction, q < .05) reduction of the intraventricular blood between day of admission and day 7 + for the third and fourth ventricle and parts of both lateral ventricles. In addition, we were able to show a significant difference between the IVF therapy and the conventionally treated group at day 4 ± 1 for the third ventricle. CONCLUSIONS The data indicate that voxel‐based analysis on group level can be used to compare the time course and the distribution of intraventricular hemorrhage. This technique could be an interesting tool for future research on ICH with IVH.

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