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Dynamic Contrast‐Enhanced MRI in Low‐Grade Versus Anaplastic Oligodendrogliomas
Author(s) -
ArevaloPerez Julio,
Kebede Amanuel A.,
Peck Kyung K.,
Diamond Eli,
Holodny Andrei I.,
Rosenblum Marc,
Rubel Jennifer,
Gaal Joshua,
Hatzoglou Vaios
Publication year - 2015
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12320
Subject(s) - medicine , oligodendroglioma , mann–whitney u test , nuclear medicine , cerebral blood volume , receiver operating characteristic , glioma , area under the curve , magnetic resonance imaging , dynamic contrast , radiology , astrocytoma , cancer research
BACKGROUND AND PURPOSE Low‐grade and anaplastic oligodendrogliomas are often difficult to differentiate on the basis of conventional MR imaging characteristics. Dynamic contrast‐enhanced (DCE) MRI can assess tumor microvasculature and has demonstrated utility for predicting glioma grade and prognosis in primary brain tumors. The aim of our study was to evaluate the performance of plasma volume (Vp) and volume transfer coefficient (K trans ) derived from DCE MRI in differentiating between grade II and grade III oligodendrogliomas. MATERIALS AND METHODS Twenty‐four consecutive patients with pathologically confirmed oligodendroglioma (World Health Organization grade II, n = 14 and grade III, n = 10) were retrospectively assessed. Pretreatment DCE MRI was performed and regions of interest were manually drawn around the entire tumor volume to calculate Vp and K trans . The Mann‐Whitney U test and receiver operating characteristic (ROC) analysis were performed to compare pharmacokinetic parameters between the 2 groups. RESULTS The Vp mean values for grade III oligodendrogliomas were significantly higher ( P = .03) than those for grade II oligodendrogliomas. The K trans mean values were higher in grade III lesions, but the difference between the 2 groups was not statistically significant ( P > .05). Based on ROC analysis, the Vp mean (area under curve = .757, SD = .1) cut‐off value that provided the best combination of high sensitivity and specificity to distinguish between grade II and III oligodendrogliomas was 2.35 ( P < .03). CONCLUSION The results of our study suggest the DCE MRI parameter Vp mean can noninvasively differentiate between grade II and grade III oligodendrogliomas.