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Nerve Ultrasound and Electrophysiology for Therapy Monitoring in Chronic Inflammatory Demyelinating Polyneuropathy
Author(s) -
Kerasnoudis Antonios,
Pitarokoili Kalliopi,
Gold Ralf,
Yoon MinSuk
Publication year - 2015
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12279
Subject(s) - medicine , chronic inflammatory demyelinating polyneuropathy , polyneuropathy , electrophysiology , ultrasound , nerve conduction , polyradiculoneuropathy , peripheral , radiology , antibody , pediatrics , guillain barre syndrome , immunology
BACKGROUND AND PURPOSE We evaluated prospectively nerve ultrasound and electrophysiology as monitoring methods of intravenous immunoglobulin (IVIG) therapy in chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS Overall 15 healthy subjects and 11 CIDP patients undergoing IVIG therapy were recruited in the study. All patients underwent clinical, ultrasound, and electrophysiological evaluation at the time point of first onset of symptoms (<6 weeks of symptoms) and 4, 8, and 12 months after onset. RESULTS The intranerve cross‐sectional area (CSA) variability of each nerve, but not the CSA alone, correlated with the MRC Scale score during 12‐month follow‐up. On the other hand, none of the electrophysiological parameters correlated with the MRC Scale Score in each of the peripheral nerves. Interestingly, in ¾ of the CIDP patients, the resolution of the conduction block correlated with the improvement in the MRC Sum score. CONCLUSIONS Nerve ultrasound and in particular the intranerve CSA variability seems to be a useful method in monitoring CIDP patients. Although the sample size is small, the intranerve CSA variability seems to be more promising than neurophysiology.