Premium
Effect of Water T2 Shortening in the Quantification of in‐vitro Proton MR Spectroscopy
Author(s) -
HernándezTamames Juan Antonio,
Mato Abad Virginia,
GarcíaÁlvarez Roberto,
GonzálezZabaleta Javier,
Pereira Loureiro Javier,
ÁlvarezLinera Juan
Publication year - 2015
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12258
Subject(s) - metabolite , in vivo , spectroscopy , nuclear magnetic resonance , in vitro , medicine , chemistry , biochemistry , biology , physics , microbiology and biotechnology , quantum mechanics
ABSTRACT PURPOSE This work studies the relationship between in‐vitro Proton Magnetic Resonance Spectroscopy metabolite quantification and water T2 decay. MATERIALS AND METHODS An in‐vitro correspondence is established between the iron accumulation and the shortening of water T2 relaxation times using seven spherical phantoms, 6 of them were doped with an increasing concentration of iron metal nanoparticles solution. This is later proposed as a source of error during the LCModel metabolite quantification of either absolute concentrations or ratios. RESULTS The Pearson's correlation coefficient between water T2 values against absolute metabolite concentrations was on average [r] = 0.97 and on average [r] = 0.85 for metabolite ratios. CONCLUSION These results suggest that the shortening of T2 values should be taken into account when performing metabolite quantification. Also, the need of demonstrated similar results in in‐vivo studies, since the presence of iron deposits or other factors affecting the water T2 decay measurements could explain part of the inter‐subject variability in the metabolite concentration and ratio quantification.