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Relative FLAIR Signal Intensities over Time in Acute Ischemic Stroke: Comparison of Two Methods
Author(s) -
Ostwaldt AnnChristin,
Galinovic Ivana,
Hotter Benjamin,
Grittner Ulrike,
Nolte Christian H.,
Audebert Heinrich J.,
Villringer Kersten,
Fiebach Jochen B.
Publication year - 2015
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12224
Subject(s) - fluid attenuated inversion recovery , medicine , radiology , stroke (engine) , acute stroke , magnetic resonance imaging , nuclear medicine , mechanical engineering , tissue plasminogen activator , engineering
BACKGROUND AND PURPOSE Visibility of lesions on fluid attenuated inversion recovery (FLAIR) images appears indicative of the time window in acute ischemic stroke. We compared two published methods for calculation of relative FLAIR signal intensities (rSI) regarding their association with time from symptom onset in a longitudinal fashion. METHODS We prospectively included patients receiving serial MRI examinations between 4.5 and 35 hours from symptom onset. FLAIR rSI was determined using two methods: a whole regions‐of‐interest (ROI) method and a hotspot method, selecting only a single area of visually highest signal. Signal intensity (rSI) was calculated relative to the contralateral side for each time point. RESULTS We included 21 patients with 3‐6 MRI examinations on the first 2 days after stroke onset. FLAIR rSI determined with both methods shows a linear association with time from onset, although the hotspot results showed higher variability. Both methods with their previously published thresholds are reliable for identifying patients outside the 4.5 hours time window. CONCLUSION Both methods show a similar performance, and might be a suitable help for the visual assessment of FLAIR lesion visibility.