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Reversible Splenial Lesion Syndrome (RESLES) Following Glufosinate Ammonium Poisoning
Author(s) -
Jeong Tae Oh,
Yoon Jae Chol,
Lee Jae Baek,
Jin Young Ho,
Hwang Seung Bae
Publication year - 2015
Publication title -
journal of neuroimaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.822
H-Index - 64
eISSN - 1552-6569
pISSN - 1051-2284
DOI - 10.1111/jon.12216
Subject(s) - splenium , medicine , corpus callosum , lesion , encephalopathy , pathology , magnetic resonance imaging , anesthesia , radiology , diffusion mri
Isolated and reversible lesion restricted to the splenium of the corpus callosum, known as reversible splenial lesion syndrome, have been reported in patients with infection, high‐altitude cerebral edema, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Here, we report a 39‐year‐old female patient with glufosinate ammonium (GLA) poisoning who presented with confusion and amnesia. Diffusion‐weighted magnetic resonance imaging of the brain revealed cytotoxic edema of the splenium of the corpus callosum. The lesion was not present on follow‐up MR imaging performed 9 months later. We postulate that a GLA‐induced excitotoxic mechanism was the cause of this reversible splenial lesion.